Alpha-1 Antitrypsin Deficiency

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Alpha-1 Antitrypsin Deficiency (often called simply “Alpha-1”) is an inherited condition that can cause liver disease in people of all ages and can lead to lung disease in adults. Alpha-1 is one of the most common inherited disorders. It accounts for about one percent of all cases of chronic obstructive pulmonary disease (COPD) in the United States.


National Jewish Health in Denver, Colorado, is one of the best places in the world to be treated for the adult lung and liver disease caused by Alpha-1. Our program has been devoted to the care of families with Alpha-1 since 1981, and our doctors have been involved in nearly every new drug evaluated for Alpha-1 treatment.

Our doctors are researchers, too, so you have access to the latest Alpha-1 clinical trials and most effective therapies.


Alpha-1 Care at National Jewish Health

At National Jewish Health, you’ll find:

  • The latest in clinical trials
  • A focused and integrated approach
  • State-of-the-art diagnostic testing
  • The latest and best therapies
  • Rehabilitation services
  • Continued follow-up to meet your changing needs.

Learn more about the Alpha-1 Treatment Program.

Our Specialists

New had happen

Investigational Medication for AATD & COPD

Do you have alpha-1 with emphysema? Our researchers want to learn if an investigational medication, a hyaluronic acid inhalation solution, can be used to treat adults who have alpha-1 antitrypsin deficiency (AATD) with emphysema.

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Reasons to Visit National Jewish Health

  • The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses
  • Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey
  • Ranked in the top 1 percent of hospitals in the nation by HCAHPS
  • Physicians frequently recognized as among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly
  • Among the top 8 percent of organizations funded for research by the NIH, providing patients access to the latest clinical trials
  • 119 -year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders


Patient Stories

Health Insights & News

Giving Help us care for patients with alpha-1. Ways to Give

#Alpha1 is one of the most common inherited disorders.

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